Open AccessFamily history of diabetes mellitus determines insulin sensitivity and ß cell function in polycystic ovary syndrome
Author(s) -
Jana Vrbíková,
Tereza Grimmichova,
Kateřina Dvořáková,
Martin Hill,
S Stanická,
K Vondra
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931275
Subject(s) - polycystic ovary , medicine , endocrinology , insulin , family history , insulin resistance , diabetes mellitus , body mass index , type 2 diabetes mellitus
Objective: To examine the impact of family history of diabetesmellitus 2 (DM 2) on insulin sensitivity and secretion in leanwomen with polycystic ovary syndrome (PCOS). Thirteen healthywomen (C), 14 PCOS without family history of DM 2 (FH-) and8 PCOS with family history of DM 2 (FH+) were examined usingeuglycemic hyperinsulinemic clamp and an arginine secretion test(insulin and glucagon at fasting glycemia (AIRFG and AGRFG) andat hyperglycemia (AIR14 and AGR14)). FH+ women were moreinsulin resistant than FH- with lower insulin sensitivity indexcorrected per lean body mass (p<0.05). They had significantlyhigher triglycerides (p<0.05) and lower HDL-cholesterol (p<0.05)than C or FH- women. Concerning insulin secretion, AIRFG wasincreased in FH+ women comparing FH- women (p<0.05).Disposition indices derived from AIRFG or AIR14 and insulinsensitivity index did not differ between FH+ or FH-. Thus, womenwith PCOS with the concomitant family history of DM 2 havelower insulin sensitivity than healthy control women. Insulinresistance observed in these women with PCOS is compensatedby increased insulin secretion.