Open AccessComparison of the obesity phenotypes related to monosodium glutamate effect on arcuate nucleus and/or the high fat diet feeding in C57Bl/6 and NMRI mice
Author(s) -
Resha Matyšková,
Lenka Maletı́nská,
Jana Maixnerová,
Zdeno Pirník,
Alexander Kiss,
Blanka Železná
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931274
Subject(s) - endocrinology , medicine , monosodium glutamate , hyperinsulinemia , obesity , leptin , calorie , insulin resistance , insulin , hyperinsulinism , weight gain , biology , body weight
In this study, susceptibility of inbred C57BL/6 and outbred NMRImice to monosodium glutamate (MSG) obesity or diet-inducedobesity (DIO) was compared in terms of food intake, bodyweight, adiposity as well as leptin, insulin and glucose levels.MSG obesity is an early-onset obesity resulting from MSGinduced lesions in arcuate nucleus to neonatal mice. Both maleand female C57BL/6 and NMRI mice with MSG obesity did notdiffer in body weight from their lean controls, but haddramatically increased fat to body weight ratio. All MSG obesemice developed severe hyperleptinemia, more remarkable infemales, but only NMRI male mice showed massivehyperinsulinemia and an extremely high HOMA index that pointedto development of insulin resistance. Diet-induced obesity is alate-onset obesity; it developed during 16-week-long feeding withhigh-fat diet containing 60 % calories as fat. Inbred C57BL/6mice, which are frequently used in DIO studies, both male andfemale, had significantly increased fat to body weight ratio andleptin and glucose levels compared with their appropriate leancontrols, but only female C57BL/6 mice had also significantlyelevated body weight and insulin level. NMRI mice were lessprone to DIO than C57BL/6 ones and did not show significantchanges in metabolic parameters after feeding with high-fat diet.