Open AccessOverweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults
Author(s) -
Klára Krontorádová,
Nataša Honzíková,
Bohumil Fišer,
Zuzaováková,
Eva Závodná,
Hana Hrstková,
Petr Honzík
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931250
Subject(s) - baroreflex , overweight , medicine , body mass index , blood pressure , receiver operating characteristic , endocrinology , cardiology , heart rate
We studied the relationship between blood pressure (BP), bodymass index (BMI, kg/m2) and baroreflex sensitivity (BRS,ms/mmHg) in adolescents. We examined 34 subjects aged16.2±2.4 years who had repeatedly high causal BP (H) and52 controls (C) aged 16.4±2.2 years. Forty-four C and 22 H wereof normal weight (BMI between 19-23.9), and 8 C and 12 H wereoverweight (BMI between 24-30). Systolic BP was recorded beatto-beat for 5 min (Finapres, controlled breathing 0.33 Hz). BRS was determined by the cross-spectral method. The predicting power of BMI and BRS for hypertension was evaluated bysensitivity, specificity, and receiver operating curve (ROC - plot ofsensitivity versus specificity). H compared with C had lower BRS(p<0.01) and higher BMI (p<0.05). Multiple logistic regressionanalysis (p<0.001) revealed that a decreased BRS (p<0.05) andan increased BMI (p<0.01) were independently associated withan increased risk of hypertension. No correlation between BMIand BRS was found either in H or in C. Following optimal criticalvalues by ROC, the sensitivity, specificity and area under ROCwere determined for: BMI - 22.2 kg/m2, 61.8 %, 69.2 %, 66.0 %; BRS - 7.1 ms/mmHg, 67.7 %, 69.2 %, 70.0 %; BMI and BRS - 0.439 a.u., 73.5 %, 82.7 %, and 77.3 %. Decreased BRSand overweight were found to be independent risk factors forhypertension.