Open AccessMathematical model indicates nonlinearity of noradrenaline effect on rat renal artery
Author(s) -
M Ďurišová,
Ladislav Dedı́k,
Viera Kristová,
R Vojtko
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931199
Subject(s) - renal artery , analysis of variance , linear regression , artery , mathematics , cardiology , medicine , kidney , statistics
The aim of this work is to present the efficacy of a previouslyintroduced computational procedure, developed for evaluation ofvascular responsiveness. On this reason, as an example acommon study of noradrenaline (NA) effect on a rat renal arteryunder in vitro conditions was arbitrarily selected. The response ofthe arterial segment to NA doses (0.1-10 μg) was digitallyrecorded on a PC and employed to develop mathematical modelof NA effect. Using the model, the following NA effect variableswere determined: the vessel sensitivity parameter, mean effecttime and rate constant, respectively, characterizing the effectintensity, duration, and regression and also classic responsevariables: the maximal effect and time of the maximal effect. Thetwo-way analysis of variance followed by Bonferroni’s testrevealed a significant influence of the increasing NA dose on thevessel sensitivity parameter and mean effect time. These findingsindicated nonlinearity of processes underlying NA effect on therat renal artery over the given range of NA doses. The procedureexemplified has the potential for use as an effective adjunct toroutine studies of vascular responsiveness as it enables theextraction of meaningful information which cannot by obtainedby common manual evaluation procedures.