Open AccessEffect of cervical sympathetic trunk transection on renal sympathetic nerve activity in rats
Author(s) -
Takehiko Ikeda,
Haruhisa Hirakawa,
Takehito Kemuriyama,
Yasuhiro Nishida,
Tomoxo Kazama
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931186
Subject(s) - medicine , baroreceptor , anesthesia , stellate ganglion , sympathetic trunk , sympathetic nervous system , blood pressure , heart rate , vagus nerve , anatomy , stimulation , alternative medicine , pathology
Stellate ganglion blockade (SGB) with a local anesthetic increasesmuscle sympathetic nerve activity in the tibial nerve in humans.However, whether this sympathetic excitation in the tibial nerveis due to a sympathetic blockade in the neck itself, or due toinfiltration of a local anesthetic to adjacent nerves including thevagus nerve remains unknown. To rule out one mechanism, weexamined the effects of cervical sympathetic trunk transection onrenal sympathetic nerve activity (RSNA) in anesthetized rats.Seven rats were anesthetized with intraperitoneal urethane.RSNA together with arterial blood pressure and heart rate wererecorded for 15 min before and 30 min after left cervicalsympathetic trunk transection. The baroreceptor unloading RSNAobtained by decreasing arterial blood pressure withadministration of sodium nitroprusside was also measured. Leftcervical sympathetic trunk transection did not have anysignificant effects on RSNA, baroreceptor unloading RSNA,arterial blood pressure, and heart rate. These data suggest thatthere was no compensatory increase in RSNA when cervicalsympathetic trunk was transected and that the increase insympathetic nerve activity in the tibial nerve during SGB inhumans may result from infiltration of a local anesthetic toadjacent nerves rather than a sympathetic blockade in the neckitself.