Open AccessEffect of serotonin on small intestinal contractility in healthy volunteers
Author(s) -
Hansen Mb,
Farah Arif,
Hans Gregersen,
H Bruusgaard,
L Wallin
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931177
Subject(s) - serotonin , contractility , medicine , endocrinology , lumen (anatomy) , duodenum , bolus (digestion) , jejunum , receptor
The physiological significance of serotonin released into theintestinal lumen for the regulation of motility is unknown inhumans. The aim of this study was to evaluate the effect ofserotonin infused into the lumen of the gastric antrum,duodenum or the jejunum, on antro-duodeno-jejunal contractilityin healthy human volunteers. Manometric recordings wereobtained and the effects of either a standard meal, continuousintravenous infusion of serotonin (20 nmol/kg/min) orintraluminal bolus infusions of graded doses of serotonin (2.5, 25or 250 nmol) were compared. In addition, platelet-depletedplasma levels of serotonin, blood pressure, heart rate andelectrocardiogram were evaluated. All subjects showed similarresults. Intravenous serotonin increased migrating motorcomplex phase III frequency 3-fold and migrating velocity 2-fold.Intraluminal infusion of serotonin did not change contractileactivity. Platelet-depleted-plasma levels of serotonin increased 2-fold following both intravenous and high doses of intraluminalinfusions of serotonin. All subjects reported minor short-livedadverse effects following intravenous serotonin stimulation, whileonly half of the subjects reported minor short-lived adverseeffects following intraluminal serotonin stimulations. We concludethat exogenous serotonin in the lumen of the upper part of thesmall intestine does not seem to change antro-duodeno-jejunalcontractility significantly in healthy adult volunteers.