Open AccessEven mild changes in free thyroxine could influence the degree of heart failure measured by its biological surrogates
Author(s) -
Oscar H. Mayer,
J Šimon,
J Čech,
Hana Rosolová,
Jana Hrbková,
Richard Pikner,
Ladislav Trefil
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931172
Subject(s) - heart failure , medicine , confounding , ventricle , natriuretic peptide , cardiology , endocrinology , odds ratio
Both, severe hypo- or hyperthyroidism may alter hemodynamicparameters. The aim of our study was to ascertain, whether alsodistinct changes within normal range of free thyroxine (fT4)would be associated with an impairment of left ventricle functionin patients with chronic heart failure. Hundred-forty-eightpatients (m121, f27, mean age 63.8±1.14 years) with chronicheart failure, fT4 levels within the normal range (9-22 pmol/l)and without thyrostatics or substitution treatment. Degree ofheart failure was quantified by plasma B-type natriuretic peptide(BNP) and N-terminal pro-BNP (NT-proBNP). Patients with fT4 inthe range 11.9-14.6 pmol/l [optimal, 2nd-3th quintile] hadsignificantly lower NT-proBNP (718±70.4 pg/ml), than those withfT4< 11.8 [low-normal, bottom quintile](1236±223.6 pg/ml;p<0.03) and those with fT4 over 14.6 pmol/l [high-normal, toptwo quintiles] (1192±114.9 pg/ml; p<0.0002). These differencesremain significant, also if adjusted for age, gender and otherconfounders; adjusted odds ratio was 1.30 (1.05-1.59) foroptimal vs. low-normal and 1.27 (1.04-1.55) for optimal vs. highnormal. Similar statistical differences were also found in BNP, butonly when optimal and high-normal fT4 ranges were compared.In conclusion, the severity of heart failure seems to be alsoinfluenced by only mild deviations of fT4 concentrations fromoptimal levels.