Open AccessEarly and late effects of hyperbaric oxygen treatment on oxidative stress parameters in diabetic patients
Author(s) -
Figen Gürdöl,
Maide Çimşit,
Yıldız Öner-İyidoğan,
Şefika Körpınar,
Şükrü Yalçınkaya,
Harun Koçak
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931139
Subject(s) - oxidative stress , malondialdehyde , reactive oxygen species , medicine , hyperbaric oxygen , endogeny , oxygen , diabetic foot , physiology , endocrinology , pharmacology , anesthesia , chemistry , diabetes mellitus , biochemistry , organic chemistry
Exposure to hyperbaric oxygen leads to increased amount ofreactive oxygen species (ROS) that are derived from varioussources. After the discovery that ROS can function as signalingmolecules, the idea of ROS being hazardous to biological tissueshas been challenged. The aim of this study was to examine thechanges in oxidative stress parameters in diabetics undergoinghyperbaric oxygen therapy (HBOT) due to foot ulcers. Twentypatients, who received HBOT for diabetic foot ulcers, wereincluded in the study. Blood samples were taken before HBOTand 30 min after exit from the chamber, on the day of the firstand the 15th HBOT sessions. They were used for thedeterminations of malondialdehyde (MDA), 8-isoprostane andadvanced oxidation protein products (AOPPs). 8-Isoprostane andAOPP levels were not altered significantly after the first HBOTsession, while both were increased on the fifteenth day (p<0.05).MDA was significantly increased only after the first HBOT session,and remained unchanged on the fifteenth day (within-dayvariations). Plasma AOPP levels were lowered significantly afterfifteen consecutive HBOT sessions (between-day variations).Decreased AOPP levels suggest that increased oxygenation oftissues due to HBO therapy may activate some endogenousfactors that prevent hazardous effects of the disease itself.