Open AccessLipoprotein (a) and its position among other risk factors of atherosclerosis
Author(s) -
Lukáš Zlatohlávek,
K. Zídková,
Michal Vráblík,
T Haas,
Martina Prusíková,
Hélèna Svobodova,
Richard Češka
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931133
Subject(s) - lipoprotein(a) , apolipoprotein b , medicine , risk factor , lipoprotein , correlation , endocrinology , coronary heart disease , gene , coronary atherosclerosis , biology , genetics , cholesterol , geometry , mathematics
Lipoprotein(a) [Lp(a)] comprises of an LDL particle andapolipoprotein(a) [apo(a)] and its elevated levels are considereda risk factor for atherosclerosis. The aim of our study was to findout whether elevated Lp(a) levels are associated with increasedrisk of atherosclerosis in patients with multiple other risk factors.We further tested the association of three polymorphisms of theapo(a) gene promoter with Lp(a) levels. No significant correlationwas detected between Lp(a) levels and lipid and clinicalparameters tested. The study demonstrated a significantly(p=0.0219) elevated Lp(a) level (mean 28±35 mg/dl, median0.14) in patients with coronary heart disease (CHD). In a groupwith premature CHD the correlation was not significant anymore.There was a significant correlation between polymorphic loci ofthe promoter region of apo(a) gene and Lp(a) levels (+93C>T,p=0.0166, STR, p<0.0001). Our study suggests that elevatedLp(a) level is an independent risk factor of CHD in carriers ofother important CHD risk factors. Observed association ofsequence variants of the promoter of apo(a) gene with Lp(a)levels is caused in part due to linkage to a restricted range ofapo(a) gene length isoforms.