Open AccessPlasma tissue factor in coronary artery disease. further step to the understanding of the basic mechanisms of coronary artery thrombosis.
Author(s) -
Jan Vojáček,
Jiří Dušek,
Bis J,
Josef Šťásek,
M. Błażek
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931091
Subject(s) - tissue factor , medicine , coronary artery disease , fibrin , thrombosis , thrombin , platelet , angiogenesis , coronary thrombosis , pathophysiology , factor vii , pathology , cardiology , immunology , coagulation
Tissue factor is a cell surface protein that is expressedconstitutively by monocytes, macrophages and fibroblasts, butalso by some other cells in response to a variety of stimuli. Themain function of the tissue factor is to form a complex with factorVII/VIIa that converts factors IX and X to their active forms.Tissue factor is also involved in the pathophysiology of systemicinflammatory disorders, coagulopathies, atherosclerotic disease,tumor angiogenesis and metastasis. Increased tissue factorexpression either locally in the coronary plaques or systematicallyon circulating blood elements of patients with acute coronarysyndromes may be responsible for increased thrombingeneration, thus leading to platelet activation and fibrinformation. Tissue factor therefore plays a pivotal role in theinitiation of thrombotic complications in patients with coronaryartery disease.