Open AccessThe role of tissue factor in thrombosis and hemostasis
Author(s) -
Malý Ma,
Pavol Tomašov,
Petr Hájek,
Peter Blaško,
Ingrid Hrachovinová,
Peter Salaj,
Josef Veselka
Publication year - 2007
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931054
Subject(s) - tissue factor , hemostasis , thrombosis , pathophysiology , coagulation , medicine , coagulation cascade , tissue factor pathway inhibitor , cardiology , platelet , thrombin
The tissue factor (TF) is one of the most important regulators of arterial thrombosis. Because arterial thrombosis is the pathophysiologic background of acute coronary syndrome, the possible impact of blocking the arterial thrombosis on its onset is a challenging problem. The investigations of TF brought a new concept of "cell-based coagulation model" which highlighted the question of blood-borne TF as a source of TF in circulating blood. In this review we summarize essential information on the pathophysiology, molecular structure, expression and distribution of TF and we propose a novel concept of blood-borne TF, suggesting the possibilities of inhibition of the coagulation cascade with newly synthetized drugs.