Open AccessGenetic susceptibility to type 1 diabetes mellitus in humans
Author(s) -
Daniela Kantárová,
Buc M
Publication year - 2007
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.930956
Subject(s) - human leukocyte antigen , diabetes mellitus , type 1 diabetes , disease , gene , insulin , pancreas , genetic predisposition , medicine , immune system , type 2 diabetes mellitus , autoimmune disease , immunology , biology , bioinformatics , endocrinology , genetics , antigen
Type 1 diabetes mellitus (DM 1A) is an autoimmune disease belonging to the most frequent chronic diseases of the childhood and young adults. DM 1A results from immune-mediated destruction of the insulin-producing beta cells of the pancreas. It is a genetically determined disease and many genes or genetic regions were found to be associated with its induction. In addition to the insulin-dependent diabetes mellitus 1 (IDDM1) gene, which marks the HLA region, and IDDM2 which marks the insulin gene, significant associations of DM 1A to other IDMM genes or genetic regions we reported. We shortly review recent achievements in the field, and the state of current knowledge.