Open AccessActions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion
Author(s) -
Cristiane Mota Leite,
Gabrielle Machado,
Rita Cássia Menegati Dornelles,
Celso Rodrigues Franci
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.930878
Subject(s) - endocrinology , medicine , prolactin , microinjection , dopamine , chemistry , angiotensin ii , inhibitory postsynaptic potential , receptor , estrogen , sulpiride , preoptic area , hypothalamus , hormone , biology , dopaminergic
Dopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectomized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of DA antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and DA actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of DA through D(2) receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of DA through D(1) receptors and in other part by inhibition of stimulatory action of DA through D(2) receptors.