Open AccessBeneficial effects of Provinols: cardiovascular system and kidney.
Author(s) -
Oľga Pecháňová,
Rita Rezzani,
Pavel Babál,
Iveta Bernátová,
Ramaroson Andriantsitohaina
Publication year - 2006
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
ISSN - 0862-8408
DOI - 10.33549/physiolres.930000.55.s1.17
Subject(s) - kidney , oxidative stress , in vivo , enos , medicine , ex vivo , wine , blood pressure , pharmacology , hemodynamics , fibrosis , endothelium , chemistry , endocrinology , nitric oxide , biology , nitric oxide synthase , food science , microbiology and biotechnology
Red wine polyphenols have been reported to exert beneficial effects in preventing cardiovascular diseases but their molecular mechanisms of hemodynamic effects on functional cardiovascular and renal changes were studied much less. The review is focused on in vitro as well as in vivo effects of red wine extract containing polyphenolic compounds (Provinols) on cardiovascular systems and kidney in relation to the molecular and biochemical mechanisms of these compounds. This review provides the evidence that Provinols is able to produce ex vivo endothelium-dependent relaxation as a result of enhanced NO synthesis. Administration of Provinols partially prevents the development of hypertension during NO deficiency and accelerates the decrease of blood pressure in already established hypertension. The effects of Provinols include prevention and/or attenuation of myocardial fibrosis, reduction of aortic wall thickening and improvement of vascular functions. These functional and structural alterations are associated with significant augmentation of NO production, seen as the increase of NO synthase activity and eNOS protein expression. Moreover, it has been documented that Provinols decreased the oxidative stress within the cardiovascular system and kidney.