Open AccessIndocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors
Author(s) -
Seonmin Choi,
San Hui Lee,
Sanghyo Park,
Sun Hwa Park,
Chaewon Park,
Joe L. Key
Publication year - 2021
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2021.62.11.1042
Subject(s) - hyaluronic acid , indocyanine green , plga , cd44 , nanocarriers , cancer cell , chemistry , fluorescence lifetime imaging microscopy , drug delivery , cancer , zeta potential , in vivo , biophysics , cytotoxicity , cancer research , medicine , biomedical engineering , pathology , fluorescence , in vitro , materials science , nanoparticle , nanotechnology , biochemistry , biology , anatomy , physics , microbiology and biotechnology , organic chemistry , quantum mechanics
Indocyanine green (ICG) is a promising agent for intraoperative visualization of tumor tissues and sentinel lymph nodes in early-stage gynecological cancer. However, it has some limitations, including a short half-life and poor solubility in aqueous solutions. This study aimed to enhance the efficacy of near-infrared (NIR) fluorescence imaging by overcoming the shortcomings of ICG using a nano-drug delivery system and improve target specificity in cervical cancer.