Open AccessUrinary Hypoxia-Inducible Factor-1alpha Levels Are Associated with Histologic Chronicity Changes and Renal Function in Patients with Lupus Nephritis
Author(s) -
Chunyang Ma,
Jiali Wei,
Feng Zhan,
Ru Wang,
Ke-Ying Fu,
Xiaoping Wan,
Zhuo-Ri Li
Publication year - 2012
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2012.53.3.587
Subject(s) - lupus nephritis , urinary system , medicine , hypoxia (environmental) , kidney , pathological , proteinuria , fibrosis , pathology , renal function , nephropathy , endocrinology , disease , chemistry , organic chemistry , diabetes mellitus , oxygen
Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular adaptation to hypoxia, regulates a wide variety of genes, some of which are closely associated with tissue fibrosis. The present study set out to characterize urinary HIF-1alpha expressions in patients with lupus nephritis (LN) and to explore whether urinary HIF-1alpha expressions are associated with histologic chronicity changes and renal function.