Open AccessVanishing Pancreatic Grafts
Author(s) -
Christopher D. Pivetti,
Ickpyo Hong,
Chang Hyun Yoo,
Sun Lee,
Kenny Kim,
Gregory Emmanuel,
Jason Kim,
R S H Chung,
Slawomir Niewiadomski,
Paul L. Wolf,
Ruben F. Gittes
Publication year - 2004
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2004.45.6.1169
Subject(s) - medicine , histology , pancreas , fibrosis , pancreatic duct , islet , pathology , insulin
Comparison of pancreaticoduodenal transplants (PDT) and duct-ligated pancreas transplant (DLPT) were performed using syngeneic and allogeneic studies in rats. Both DLPT and PDT allogeneic grafts showed mild rejection. DLPT groups showed disorganized pathology and acini replaced by fat. Eventually, massive fibrosis was seen in the Islets of Langerhans, as well as rejection cellular infiltrates. In both PDT groups, normal histology was observed in the same period. Thus the effect of duct occlusion is highly detrimental for the grafts.