Open AccessGonadal Tumors Developed from Consecutively Transplanted Spleens Bearing Gonad Implants
Author(s) -
Ickpyo Hong,
Sun Lee,
Chang Hyun Yoo,
Kenny K. Kim,
Jason Kim,
Gregory Emmanuel,
Slawomir Niewiadomski,
Paul L. Wolf,
Ruben F. Gittes
Publication year - 2004
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2004.45.6.1136
Subject(s) - dysgerminoma , gonad , spleen , transplantation , medicine , ovary , implant , andrology , pathology , biology , surgery , anatomy
This study was conducted by consecutively transplanting spleens, which had gonads implanted previously. A total of 84 cases for infantile testicles and 106 cases for ovarian follicles were performed. In the case of ovarian implants, the results were determined by the total number of follicle implants. A modified spleen transplantation technique called double implantation of ovarian follicles was applied to increase the amount of the implants. In this technique, an extra spleen is implanted into the potential donor so that the ovarian follicles can be implanted to two different spleens, doubling the amount of implants. Through consecutive spleen transplantation, we observed the results beyond a typical rat's life span. In many of these cases, we found more aggressive forms of malignant tumor, seminoma and dysgerminoma. We present the results and discuss possible pathogenic mechanisms of tumor formation.