Involvement of MAP Kinases in Apoptosis of Macrophage Treated withTrichomonas vaginalis | Zendy

Yong Suk Ryang | Zendy; Jae Ho Chang | Zendy; Ju Youn Park | Zendy

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Involvement of MAP Kinases in Apoptosis of Macrophage Treated withTrichomonas vaginalis

Author(s) -

Yong Suk Ryang,

Jae Ho Chang,

Ju Youn Park

Publication year - 2004

Publication title -

yonsei medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.702

H-Index - 63

eISSN - 1976-2437

pISSN - 0513-5796

DOI - 10.3349/ymj.2004.45.4.751

Subject(s) - trichomonas vaginalis , p38 mitogen activated protein kinases , kinase , signal transduction , apoptosis , mapk/erk pathway , microbiology and biotechnology , biology , phosphorylation , western blot , mitogen activated protein kinase , dna fragmentation , protein kinase a , programmed cell death , biochemistry , gene

A primitive protozoan parasite Trichomonas vaginalis selectively activates the signal transduction pathways in macrophages (RAW264.7). This study evaluated the correlation of these signaling pathways and T. vaginalis-induced cell apoptosis. In macrophages infected with T. vaginalis, apoptosis was assessed on the basis of DNA fragmentation on agarose gel electrophoresis. Infection of macrophages with T. vaginalis induced tyrosine phosphorylation of several proteins. Infected cells with T. vaginalis were shown to associate with phosphorylation of the extracellular signal-regulated (ERK)1/2 kinase, p38, c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases on Western blot analysis. The present finding also demonstrated a link between the ERK1/2, JNK and p38 apoptotic pathways that was modulated by T. vaginalis infection.

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