Open AccessInherited Vitamin K Deficiency: Case Report and Review of Literature
Author(s) -
Zerrin Orbak,
Ayşe Selimoğlu,
Hakan Döneray
Publication year - 2003
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2003.44.5.923
Subject(s) - osteocalcin , endocrinology , vitamin k deficiency , medicine , carboxylation , vitamin , alkaline phosphatase , vitamin d deficiency , parathyroid hormone , vitamin d and neurology , chemistry , enzyme , biochemistry , calcium , catalysis
Vitamin K is the cofactor for the hepatic carboxylation of glutamic acid residues in a number of proteins including the procoagulants factors II, VII, IX, and X. The role of vitamin K in normal bone function is not fully understood. Inherited deficiency of vitamin K dependent coagulation factors is a rare bleeding disorder reported only in a few patients. Here we present an 18-month old child who presented with osteopeni due to inherited vitamin K deficiency. While the patient had high bone specific alkaline phosphatase and parathyroid hormone levels and low osteocalcin and bone mineral density values, with the regular supplementation of vitamin K all the mentioned parameters returned to normal values.