Open AccessAssignments of the tyrosinase related protein-1 and -2 genes to human chromosome bands 9p23 and 13q32.1 byin situhybridization
Author(s) -
Young Mi Lee,
Mahn Joon Ha,
Min Sook Ryu,
Eunpyo Moon,
Sang Hee Im,
Hyon Ju Kim,
Wankee Kim
Publication year - 2000
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.2000.41.3.398
Subject(s) - gene , fluorescence in situ hybridization , microbiology and biotechnology , biology , chromosome , genetics , gene mapping , bacterial artificial chromosome , in situ , chemistry , genome , organic chemistry
To determine the precise chromosomal localization of tyrosine related protein-1 and -2 (TRP-1 and TRP-2) genes by fluorescence in situ hybridization, we used DNAs isolated from human bacterial artificial chromosome clones. They contain genomic sequences with approximately 120 kb inserts for TRP-1 and TRP-2. The TRP-1 and TRP-2 genes were assigned to human chromosome bands 9p23 and 13q32.1, respectively. These results confirmed the previously mapped location for the TRP-1 gene and more precisely located the TRP-2 gene, which had previously been mapped to chromosome 13q31-q32.