Open AccessIncidence and possible reasons for discordant results between positive FDP and negative D-dimer latex assays in clinical specimens
Author(s) -
Kyung Soon Song,
Young Ah Kim,
Hyun Kyung Kim,
Quehn Park
Publication year - 1999
Publication title -
yonsei medical journal/yonsei medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 63
eISSN - 1976-2437
pISSN - 0513-5796
DOI - 10.3349/ymj.1999.40.2.107
Subject(s) - latex fixation test , d dimer , fibrinolysis , medicine , agglutination (biology) , fibrin , incidence (geometry) , coagulation , turbidimetry , fibrinogen , gastroenterology , immunoassay , immunology , antibody , chromatography , chemistry , physics , optics
In general, FDP and D-dimer values have a correlation in clinical conditions associated with disseminated intravascular coagulation(DIC) or coagulation activation. However, there are some patients with discordant results who demonstrate elevated FDP and negative D-dimer results by latex agglutination assays. The incidence and possible reasons for the discordance between FDP and D-dimer results were investigated through simultaneous measurements (n = 763) from clinical patients with suspected DIC or coagulation activation. 24.8% (189/763) of samples with elevated FDP were negative for D-dimer assays by the latex agglutination method. Further detailed analysis on randomly-selected discordant samples (n = 41) revealed that the most common reason for the discordance was the lower sensitivity of the semiquantitative latex agglutination method for D-dimer, compared with quantitative enzyme or other latex immunoassay. The other contributing factors to the discordance were accelerated fibrinogenolysis without secondary fibrinolysis, elevated soluble fibrin monomer and rheumatoid factor.