Open AccessMegalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report
Author(s) -
Hee Jin Kwon,
Kwai Han Yoo,
In Young Kim,
Seulkee Lee,
Hye Ryoun Jang,
Ghee Young Kwon
Publication year - 2015
Publication title -
journal of korean medical science/journal of korean medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 66
eISSN - 1598-6357
pISSN - 1011-8934
DOI - 10.3346/jkms.2015.30.1.110
Subject(s) - medicine , bacteremia , interstitial nephritis , nephritis , renal biopsy , renal function , antibiotics , acute kidney injury , kidney disease , kidney , bacteriuria , gastroenterology , pathology , urology , microbiology and biotechnology , urinary system , biology
Megalocytic interstitial nephritis is a rare form of kidney disease caused by chronic inflammation. We report a case of megalocytic interstitial nephritis occurring in a 45-yrold woman who presented with oliguric acute kidney injury and acute pyelonephritis accompanied by Escherichia coli bacteremia. Her renal function was not recovered despite adequate duration of susceptible antibiotic treatment, accompanied by negative conversion of bacteremia and bacteriuria. Kidney biopsy revealed an infiltration of numerous histiocytes without Michaelis-Gutmann bodies. The patient's renal function was markedly improved after short-term treatment with high-dose steroid.