Open AccessSerotonin Transporter Gene Polymorphisms and Chronic Illness of Depression
Author(s) -
Woojae Myung,
Seong Woo Lim,
Jin-Woo Kim,
Yujin Lee,
Jaeki Song,
Ki-won Chang,
Doh Kwan Kim
Publication year - 2010
Publication title -
journal of korean medical science/journal of korean medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 66
eISSN - 1598-6357
pISSN - 1011-8934
DOI - 10.3346/jkms.2010.25.12.1824
Subject(s) - serotonin transporter , depression (economics) , odds ratio , 5 httlpr , logistic regression , medicine , polymorphism (computer science) , confidence interval , genetics , genotype , variable number tandem repeat , gene , biology , economics , macroeconomics
Clinical course of depression is variable. The serotonin transporter gene is one of the most studied genes for depression. We examined the association of serotonin transporter gene polymorphisms with chronicity and recurrent tendency of depression in Korean subjects. This cross-sectional study involved 252 patients with major depression. Patients were genotyped for s/l polymorphisms in 5-HTT promoter region (5-HTTLPR), s/l variation in second intron of the 5-HTT gene (5-HTT VNTR intron2). Chronicity was associated with 5-HTTLPR. Patients with l/l had higher rate of chronicity than the other patients (l/l vs s/l or s/s; odds ratio, 4.45; 95% confidence interval, 1.59-12.46; P=0.005; logistic regression analysis). Recurrent tendency was not associated with 5-HTTLPR. Chronicity and recurrent tendency were not associated with 5-HTT VNTR intron2. These results suggest that chronic depression is associated with 5-HTTLPR.