Open AccessImmunogenicity and Safety of Diphtheria-tetanus Vaccine in Adults
Author(s) -
JungHyun Choi,
Eun Ju Choo,
Aejung Huh,
Su-Mi Choi,
Joong Sik Eom,
Jin Seo Lee,
Sun Hee Park,
Jin Han Kang
Publication year - 2010
Publication title -
journal of korean medical science/journal of korean medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 66
eISSN - 1598-6357
pISSN - 1011-8934
DOI - 10.3346/jkms.2010.25.12.1727
Subject(s) - diphtheria , tetanus , medicine , vaccination , immunogenicity , adverse effect , diphtheria toxin , immunity , immunology , pediatrics , corynebacterium diphtheriae , antibody , immune system , microbiology and biotechnology , toxin , biology
This study was conducted to evaluate the immunogenicity and safety of diphtheria-tetanus (Td) vaccine in adults over 40 yr old who had never received a diphtheria-tetanus-pertussis (DTP) vaccination. A total of 242 subject completed three-doses of Td vaccination and subsequent assays for immunogenicity. Before vaccination, 33.9% and 96.7% participants showed antibody levels of diphtheria and tetanus, respectively, which were below protective level (<0.1 U/mL). After the first dose of Td vaccine, 92.6% and 77.6% of subjects gained protective antibody concentrations (≥ 0.1 U/mL) for diphtheria and tetanus, with an increase to 99.6% and 100% after the third dose. Local and systemic adverse events occurred in 37.9% and 15.5% of the subjects. No serious adverse event requiring an unscheduled hospital visit occurred. In conclusion, three-doses of Td vaccination to unimmunized adults are safe and effective in inducing protective immunity against diphtheria and tetanus.