Open AccessAssociation between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy
Author(s) -
Seung-Ah Baek,
WonHo Hahn,
Byoung-Soo Cho,
Sung-Do Kim
Publication year - 2010
Publication title -
korean journal of pediatrics/korean journal of pediatrics
Language(s) - English
Resource type - Journals
eISSN - 2092-7258
pISSN - 1738-1061
DOI - 10.3345/kjp.2010.53.2.215
Subject(s) - medicine , proteinuria , snp , genotype , single nucleotide polymorphism , nephropathy , gastroenterology , allele , pathological , significant difference , immunology , endocrinology , gene , kidney , genetics , diabetes mellitus , biology
Purpose : Interleukin-17 (IL-17) is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA nephropathy (IgAN). Our aim was to investigate the association between single-nucleotide polymorphisms (SNPs) in IL-17 receptor A (IL-17RA) gene and childhood IgAN. Methods : We analyzed the SNPs in the IL-17RA in 156 children with biopsy-proven IgAN and 245 healthy controls. We divided the IgAN patients into 2 groups and compared them with respect to proteinuria (?#180; and >4 mg/m2/h, ?#180;0 and >40 mg/m2/h, respectively) and the presence of pathological levels of biomarkers of diseases such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : No difference was observed between the SNP genotypes rs2895332, rs1468488, and rs4819553 between IgAN patients and control subjects. In addition, no significant difference was observed between allele frequency of SNPs rs2895 332, rs1468488, and rs4819553 between patients in the early and advanced stage of the disease. However, significant difference was observed between the genotype of SNP rs2895332 between patients with proteinuria (>4 mg/m2/h) and those without proteinuria (codominant model OR 0.36, 95% CI 0.19–0.66, P<0.001; dominant model OR 0.35, 95% CI 0.17–0.69 P=0.002; recessive model OR 0.12, 95% CI 0.01–1.06 P=0.025). Conclusion : Our results indicate that the SNP in IL-17RA (rs2895332) may be related to the development of proteinuria in IgAN patients