Open AccessInflammatory pathways involved in adipose tissue hypertrophy and the effect of Acai (Euterpe oleracea Martius) on the modulation of this process: a review
Author(s) -
Tamires Cássia de Melo Souza,
Gabriel Vitor de Melo Souza,
Ana Carolina Pinheiro Volp
Publication year - 2020
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v9i9.6813
Subject(s) - inflammation , adipose tissue , medicine , bioinformatics , narrative review , in vivo , pharmacology , biology , microbiology and biotechnology , intensive care medicine
Adipose tissue plays an important role in chronic inflammation and the presence of bioactive compounds in food has been widely discussed as a means of prevention and treatment of various pathological conditions. The aim of this review is to promote an overview and elucidate pathways involved in the chronic inflammatory process triggered by adipose tissue hypertrophy and to discuss data related to the use of Acai in the modulation of inflammation. Initially, a narrative review was carried out on metabolic and molecular pathways involved in the process of subclinical chronic inflammation (NF-κB, AP-1, cross-talk between macrophages and adipocytes, increased LPS and Nrf2 pathway). Then, an integrative review was carried out on the effect of Acai in processes of chronic subclinical inflammation in humans. The database consulted was PubMed, in which the name of the fruit was crossed with the descriptors "inflammation" and "chronic diseases", prioritizing in vivo and in vitro studies related to the human species, carried out in the last ten years. It was observed that the immunomodulatory effects of Acai are increasingly clear, however, are not enough to classify the fruit as a tool in the treatment and prevention of metabolic diseases. To make possible more comprehensive inferences, it is necessary that future studies include assessment of the bioavailability of the bioactive compounds present, in addition to being performed using more suitable methods, with humans, containing sample size calculation, control group and placebo.