Open AccessHaloperidol increases hepatic lipid peroxidation promoted by high-fat diet in rats
Author(s) -
Ilson Dias da Silveira,
Daniel Henrique Roos,
Andréia Caroline Fernandes Salgueiro,
Vanderlei Folmer,
João Batista Teixeira da Rocha,
Robson Luiz Puntel
Publication year - 2020
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v9i2.2153
Subject(s) - lipid peroxidation , haloperidol , endocrinology , medicine , intracellular , chemistry , biochemistry , oxidative stress , dopamine
This study aimed to evaluate the effects of the treatment with haloperidol (HAL) associated with a high-fat diet (HF) on hepatic and renal damage, intracellular magnesium (Mg2+) levels, and abdominal fat content. Young male Wistar rats were fed with high-fat diet or control diet during 48 weeks and, at the 24-week, part of animals began to be co-treated with HAL (1 mg/Kg/day intramuscularly). After 4 weeks of the drug administration, the livers and kidneys were removed for analyses. The results showed that HF diet significantly increased lipid peroxidation in the hepatic tissue of treated animals, when compared to animals treated with control diet (P<0.05). Moreover, HF associated with HAL further increased the hepatic lipid peroxidation levels (P<0.05). In contrast, HF and/or HAL did not promote significant changes in renal lipid peroxidation levels. We also found a negative correlation between intracellular Mg2+ levels and abdominal fat content among all animals. In conclusion, the data presented suggest adverse interactions between HAL and HF on liver. Furthermore, the negative correlation between the intracellular Mg2+ levels and the abdominal fat accumulation suggest a possible involvement of Mg2+ in the metabolic syndrome development associated with a HF diet.