Open AccessShort-term comparison between clinical and microbial profiles in diabetic and non-diabetic patients with chronic periodontitis after non-surgical periodontal therapy
Author(s) -
Gabriela Alessandra da Cruz Galhardo Camargo,
Marcelo Magalhães Cortês,
Ana Carolina Organista Cörner,
Daniela Alvim Chrisostomo,
Cristiane Duque
Publication year - 2022
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v11i4.27270
Subject(s) - aggregatibacter actinomycetemcomitans , prevotella intermedia , tannerella forsythia , medicine , chronic periodontitis , porphyromonas gingivalis , periodontitis , gastroenterology , diabetes mellitus , candida glabrata , gingival and periodontal pocket , candida tropicalis , candida albicans , treponema denticola , microbiology and biotechnology , dentistry , endocrinology , pathology , biology , alternative medicine , traditional chinese medicine , honeysuckle
Aim: To compare clinical and microbial profiles in type 2 diabetic (DM) and non-diabetic (NDM) patients with chronic periodontitis after non-surgical periodontal therapy. Methods: 30 subjects with periodontitis were separated into two groups: 15 DM and 15 NDM. Blood parameters and clinical parameters were assessed. Subgingival biofilm samples were collected from periodontal pockets (PD > 5mm) and ckecked by the presence of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Prevotella intermedia (Pi), Campylobacter rectus (Cr), Candida albicans (Ca), Candida glabrata (Cg), Candida tropicalis (Ct), Candida dublinienses (Cd) by Polymerase Chain Reaction. Data were statistically analyzed, considering p < 0.05. Results: PI, PD, and CAL significantly reduced after 3 months of periodontal therapy in both groups. Only levels of HbA1c reduced in the DM group after 3 months. Comparisons between baseline and 3 months after periodontal therapy revealed a reduction of Aa, Pg, Tf, Pi, Ct and Cd for the NDM group and Aa, Pg, Tf, and Ca for the DM group. Conclusions: The periodontal therapy was effective in reducing clinical parameters and microbial levels, regardless the presence of the diabetes mellitus. However, high levels of Candida ssp. remained in periodontal pockets of diabetic patients even after therapy.