Open AccessAssociation between the use of female hormones and the thrombin generation: Cross-sectional analysis of the Longitudinal Study on Adult Health (ELSA-Brasil)
Author(s) -
Thaís Resende Batista,
Sandhi Maria Barreto,
Ana Paula Ferreira da Silva,
Wander Valadares de Oliveira Júnior,
Chams Bicalho Maluf,
Antônio Luiz Pinho Ribeiro,
Maria das Graças Carvalho,
Rachel Figueiredo,
Danyelle Romana Alves Rios
Publication year - 2021
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v10i9.17888
Subject(s) - longitudinal study , cross sectional study , medicine , hormone , thrombin generation , association (psychology) , thrombin , endocrinology , psychology , pathology , platelet , psychotherapist
The thrombin generation assay (TGA) assesses the risk of developing thrombotic events. The aim of this study was to investigate the association between the use of oral contraceptives (OCs) and hormone therapy (HT) with the TGA and resistance to activated protein C (APC). Methods: Cross-sectional study with women from the Longitudinal Study of Adult Health (ELSA-Brasil). TGA was performed by the CAT method. Results: There was an association between all parameters of the TGA and the use of OCs and an association of lag time and peak time with the use of HT. Conclusion: The TGA allows us to assess the hypercoagulability status and may be useful in the management of female hormones users.