Open AccessIn vivo transdifferentiation, osteoconductive and osteoinductive properties of experimental water-soluble organo-biomaterials – A Pilot Study
Author(s) -
Viviane Rozeira Crivellaro,
Gilvan Spada,
Cláudia Salete Judachesci,
Paula Porto Spada,
Luiza Rodrigues Saling,
Idélcena Tatiane Miranda,
Tatiana Miranda Deliberador,
Marilisa Carneiro Leão Gabardo,
Rafaela Scariot,
Moira Pedroso Leão,
Carmen Lúcia Mueller Storrer,
Sharukh Khajotia,
Fernando Luis Esteban Florez,
João César Zielak
Publication year - 2021
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v10i5.15017
Subject(s) - biomaterial , in vivo , chemistry , analysis of variance , biomedical engineering , materials science , dentistry , medicine , biology , microbiology and biotechnology
Inorganic bovine bone matrix (IBBM) is a biomaterial with proven osteoconductive functionalities. The objective of this study was to assess the in vivo bone regeneration functionalities of IBBM modified or not by an experimental MOE in sheep. MOE synthesis was performed by suspending nacre particles (0.05 g, diameters 0.05) were found on IM analysis (CD34, Vimentin, PREF-1, Wnt3a). Results indicated that experimental materials (IBBM+MOE) display promising functionalities. Additional studies are necessary to define biomaterials’ longitudinal effects and long-term biocompatibility properties.