Open AccessHandgrip Strength is more associated with blood glucose than ACE and AGT polymorphisms in hemodialysus patients
Author(s) -
Anderson Sola Haro,
Thiago dos Santos Rosa,
Hugo de Luca Corrêa,
Rodrigo Vanerson Passos Neves,
Michel Kendy Souza,
Fernando Costa,
José Adeirton,
Carmen Tzanno Branco Martins,
Luiz Henrique Peruchi,
Whitley J. Stone,
Jonato Prestes,
João Alexandre Ribeiro Gonçalves Barbosa,
Sandro Soares de Almeida,
Ronaldo Carvalho Araújo,
Reury Frank Pereira Bacurau
Publication year - 2021
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v10i5.14369
Subject(s) - medicine , glycemic , diabetes mellitus , endocrinology , polymorphism (computer science) , angiotensin converting enzyme , kidney disease , allele , gastroenterology , blood pressure , biology , genetics , gene
Background: Patients with chronic kidney disease (CKD) often present with comorbidities like hypertension and diabetes. These conditions are often associated with loss of strength, which is a strong predictor of mortality. In this sense, it is reasonable to investigate genetic and physiological markers that could be related to strength and identify variables associated with this phenomenon. Objective: This study aimed to investigate the influence of angiotensin-1 converting enzyme (ACE) and angiotensinogen (AGT) M235T polymorphisms, and blood glucose on handgrip strength (HGS) for CKD patients with and without diabetes mellitus (DM). Methods: Male patients (n = 84) participated in this cross-sectional study. Patients were grouped based on the diagnosis of DM or not. We evaluated HGS using a dynamometer and ACE and AGT polymorphism by polymerase chain reaction. Results: There were differences in HGS between groups. Follow up analyses indicated a difference in the distribution of ACE polymorphism alleles was associated with the reduction in HGS in the DM group. The same response was present for AGT. A negative correlation existed between blood glucose levels and HGS (r = -0.334 with p < 0.05). Discussion: The present data suggests that there is a relationship between physical capacity and poor glycemic control. Conclusion: Our study demonstrated that blood glucose levels are associated with HGS in patients with CKD independent of ACE I/D and AGT M235T polymorphisms. Presence of DM may influence functional strength retention.