Open AccessLeishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
Author(s) -
Cristiane Ferreira Lopes de Araújo,
Josué Ribeiro da Silva Nunes,
Rogério Alexandre Nunes dos Santos,
Fabrício Rios-Santos
Publication year - 2021
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v10i3.12949
Subject(s) - enalaprilat , leishmaniasis , in vitro , cytokine , nitric oxide , immunology , leishmania , pharmacology , leishmania major , chemistry , medicine , biology , angiotensin converting enzyme , parasite hosting , ace inhibitor , biochemistry , world wide web , computer science , blood pressure
Leishmaniasis is neglected diseases; the drugs used have significant toxic effects that compromise patient compliance, and increased loss of efficacy due to increased resistant infectious strains. Assays on Swiss mice infected with Leishmania brasiliensis and treated with Angiotensin-Suppressing Enzyme (ACE) inhibitors showed that, in addition to the classical effects on the cardiovascular system, some of these inhibitors had effects on nonhemodynamic, immunomediated functions such as cytokine production. In this study, the effect of enalaprilate on nitric oxide (NO) production and cytokines were evaluated, i.e., interleukins-10 and 12 and IFN-γ in J774 A.1 macrophages infected by Leishmania braziliensis. Enalaprilate demonstrated in vitro immunomodulatory capacity, increasing the release of NO to induce IL-12 and IFN-γ also decreasing il-10 release.