Open AccessComorbidities increase the risk of severity and mortality in COVID-19 patients: a systematic review and meta-analysis
Author(s) -
Edilson Leite de Moura,
Jean Moisés Ferreira,
Ana Caroline Melo dos Santos,
Denise Macêdo da Silva,
Maria Lidiane Ferreira da Silva,
Gleyce Kelly Marques de Oliveira Silva,
Pedro Henrique Nobre Silva,
José Anderson dos Santos,
Marcos Antônio da Silva Barbosa,
Abel Barbosa Lira Neto,
Aline Cristine Pereira e Silva,
Carlos Alberto de Carvalho Fraga,
Karol Fireman de Farias,
Elaine Virgínia Martins de Souza Figueiredo
Publication year - 2021
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v10i2.12533
Subject(s) - medicine , meta analysis , confidence interval , comorbidity , odds ratio , diabetes mellitus , retrospective cohort study , covid-19 , kidney disease , disease , cohort study , infectious disease (medical specialty) , endocrinology
Several studies have shown that patients with comorbidities present a poor clinical outcome of COVID-19, but the conclusions are not yet consolidated. We conducted a meta-analysis to evaluate the relationship between the preexistent conditions (comorbidities) in patients infected with SARS-CoV-2 and the outcome of COVID-19. Methods: PubMed, Science Direct, ISI Web of Science and Scopus databases were examined up to November 2020. We calculated the pooled odds ratio (OR) with 95% confidence interval, using fixed-effects or random-effects models. Results: A total of 48 retrospective cohort studies with 344,290 COVID-19 patients were included in the meta-analysis. The pooled results showed that hypertension, diabetes, cardiovascular, chronic pulmonary, chronic kidney and cerebrovascular diseases increase the risk of severity and mortality in COVID-19 patients. Moreover, malignancy was associated with an increased risk of death from COVID-19. Conclusions: The comorbidities previously mentioned may be important predictors of poor outcome of COVID-19, contributing to the prognosis of severe cases of the disease.