Open AccessLipid profile and nutritional status of a pediatric population with sickle cell anemia: differences between gender and association with severity markers
Author(s) -
Nilcemar Rodrigues Carvalho Cruz,
Thaisa Netto Souza Valente,
Fernanda Oliveira Ferreira,
Leandro Roberto de Macedo,
Andreza da Silva Brito Rocha,
Dayenne Paula Nascimento,
Antônio Frederico de Freitas Gomides,
Maria Anete Santana Valente,
Jacqueline Isaura AlvarezLeite,
Cibele Velloso-Rodrigues
Publication year - 2021
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v10i10.18934
Subject(s) - body mass index , apolipoprotein b , medicine , anemia , white blood cell , hemoglobin , lactate dehydrogenase , sickle cell anemia , endocrinology , high density lipoprotein , population , cholesterol , hemolysis , lipid profile , physiology , immunology , biology , disease , biochemistry , environmental health , enzyme
Objective: To investigate the associations between nutritional status and lipid profile with biomarkers of hemolysis and inflammation in sickle cell anemia, in addition to considering gender differences. Methods: This cross-sectional study analyzed nutritional, and biochemical data of pediatric patients carrying sickle cell anemia. Results: Vitamin A, apolipoprotein B, total cholesterol, low-density lipoprotein, and non-high-density lipoprotein cholesterol were lower in boys. Hemoglobin was significantly lower, and the white blood cells and lactate dehydrogenase were higher in boys. Body mass index, vitamin A, and triglycerides were associated with hemoglobin levels, while apolipoprotein A-I was associated with white blood cells and total bilirubin. Additionally, body mass index and vitamin A were associated with lactate dehydrogenase. Vitamin A showed significant predictive power in hemoglobin alteration and lactate dehydrogenase, while apolipoprotein A-I was able to predict high white blood cells values and total bilirubin. Conclusion: This study found in a pediatric population with sickle cell anemia that body mass index, vitamin A, triglycerides, and apolipoprotein A-I were associated with biomarkers of hemolysis and inflammation. Boys exhibited the greater nutritional deficit and severity of the disease.