Open AccessIncreased sympathetic tone of the autonomic nervous system as a factor for coronary heart disease
Author(s) -
N. l. Ingula,
N. Svyrydova
Publication year - 2018
Publication title -
shìdno-êvropejsʹkij nevrologìčnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2663-8444
pISSN - 2411-5797
DOI - 10.33444/2411-5797.2017.3(15).32-35
Subject(s) - medicine , disease , cardiology , sympathetic nervous system , pathogenesis , cause of death , autonomic nervous system , blood pressure , risk factor , population , endothelin receptor , epidemiology , heart rate , receptor , environmental health
Cardiovascular disease (CVD) in the XXI century continues to hold the lead as the leading cause of death worldwide and in Ukraine (65.2%). Coronary heart disease (CHD) is the leading place among the causes of death and disability in working-age people worldwide. In Ukraine, the analysis of mortality from CHD is 491.91 per 100 thousand population. Numerous epidemiological studies have shown that the increased activity of the sympathetic nervous system (SNS) leads to an increase in cardiovascular disease and mortality. It is known that SNS may participate in the formation of atherosclerosis by activating platelets with the subsequent formation of platelet growth factor and contributes to mechanical damage to the vessel wall as a result of high blood pressure and increased blood flow velocity. There are data on the mechanisms of interaction of SNS the vascular endothelium. Vasoconstrictor effect of endothelin-1 plays an important role in the pathogenesis of various cardiovascular diseases, among which includes the CHD.