Open AccessGlutathione system state in a hemolysate of erythrocytes among the patients with chronic cerebral ischemia
Author(s) -
А. В. Демченко
Publication year - 2016
Publication title -
shìdno-êvropejsʹkij nevrologìčnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2663-8444
pISSN - 2411-5797
DOI - 10.33444/2411-5797.2016.4(10).37-43
Subject(s) - glutathione , glutathione reductase , glutathione peroxidase , homocysteine , medicine , ischemia , endocrinology , gpx3 , chemistry , enzyme , biochemistry
The purpose of the work is to study a glutathione system (level of reduced glutathione and activity of glutathione-dependent enzymes) in a hemolysate of erythrocytes among the patients with chronic cerebral ischemia (CCI).
It was examined 287 patients with CCI and 50 healthy people without any signs of cerebrovascular disease using clinical and neuropsychological, laboratory and instrumental methods of investigation. It was established a significant decrease of the reduced glutathione concentration, the decrease of glutathione reductase and glutathione peroxidase and the increase of glutathione transferase activity in a hemolysate of erythrocytes among the patients with chronic cerebral ischemia in comparison with these rates among healthy people. It was established a negative correlated connection between the level of the reduced glutathione, the age of the patients (r=-0,34, р<0,0001), the stage of discirculatory encephalopathy (DE) (r=-0,50, р<0,0001), intima media complex thickness of carotid arteries (r=-0,29, р=0,009), the level of homocysteine (r=-0,81, р<0,0001) and also the level of glutathione peroxidase, the stage of DE (r=-0,39, р<0,0001) and homocysteine level (r=-0,60, р<0,0001).