Clinical and neurophysiological assessment of cognitive functions during the treatment of patients with chronic brain ischemia

Purpose. To develop the optimal combination of methods of neuropsychological and neurophysiological diagnosis for objectification of cognitive function in patients with chronic brain ischemia, the reasoning of differentiated selection of criterias for complex treatment that includes medication and non-pharmacological methods for patient’s recovery and professional adaptations. Materials and methods. 30 patients were examined. To all of them was conducted clinical and neurological examination, MRI, neuropsychological testing using a scale (HADS, MoCA, professional maladjustment, MBІ), ultrasound of head and neck vessels, electroencephalography (EEG) with mapping, registration of cognitive auditory evoked potentials (CEP) P300. Results. The most pronounced changes were registered in units of optical-spatial perception (30%), math skills (23%), short-term memory (30%), (p <0,05). In 70% of cases- registered professional maladjustment symptoms (p <0,05). Patients of the I-st group with hypertensive changes at the main arteries of the head and neck (according to ultrasound) marked a significant change in the parameters of the CEP: 85% decrease in an amplitude and increase in latency of P300 peak, reduction of the amplitude of the peak N2; in 66% of cases was reduced only peak amplitude N2. Was determined the relationship between the results of the neuropsychological and neurophysiological methods and cerebral blood flow in patients with chronic brain ischemia. Conclusion. There was developed a complex method of comprehensive neurophysiological (NP) and neuropsychological (NP) testing of the cognitive functions tha provides an objective evaluation of pathological changes in mnestical/intellectual capabilities of the patient, such as attention, memory, professional adaptation in patients with chronic brain ischemia.