Open AccessMagnetic Nanoparticles: An Optimization Design Approach for a Targeted Drug Release Using an AC Magnetic Field
Author(s) -
Stephanie T N A Sackeyfio,
Shawn Michael McGinley,
Saion Sinha
Publication year - 2021
Publication title -
international journal of biomedical research and practice
Language(s) - English
Resource type - Journals
ISSN - 2769-6294
DOI - 10.33425/2769-6294.1008
Subject(s) - magnetic nanoparticles , nanoparticle , nanotechnology , drug delivery , materials science , magnetic field , doxorubicin , drug , targeted drug delivery , iron oxide nanoparticles , pharmacology , physics , medicine , chemotherapy , surgery , quantum mechanics
Magnetic Nanoparticles while very versatile, show a promising and innovative method in drug targeting to help increase efficacy. The optimization of magnetic nanoparticles through the application of an AC magnetic field will enhance the release of cytotoxic drugs at the target area whilst preventing effects on healthy tissues. This article presents a study that describes the development of a Manganese Iron Oxide (MnFe2O4) magnetic nanoparticle showing a therapeutic effect on T47D cells using Doxorubicin in a DC magnetic field. It also introduces and dissects the core of magnetic nanoparticles, its applications as well as the breakdown of a design approach that can be employed to enhance drug delivery to localized sites. In addition, it shows a comprehensive technique through mathematical modeling and discusses the AC susceptibility of these unique drug vehicles; magnetic nanoparticles.