Open AccessA New View on Duchenne Muscular Dystrophy
Author(s) -
L P Grinio
Publication year - 2021
Publication title -
neurology - research and surgery
Language(s) - English
Resource type - Journals
ISSN - 2641-4333
DOI - 10.33425/2641-4333.1040
Subject(s) - dystrophin , duchenne muscular dystrophy , gene , muscular dystrophy , utrophin , gene product , organism , genetics , biology , mutation , microbiology and biotechnology , gene expression
Duchenne Muscular Dystrophy is the result of mutation gene-dystrophine, product - protein-dystrophin presents in organism as the complexes proteins placing everywhere, their role unclear. Suppose all dystrophine complexes work as one functional System D, thanks signal ability complexes. Suppose the System D the ancient and appeared when the gene dystrophin-utrophin divided into two genes dystrophin and utrophin at early vertebrates. Perfect this System made the gene the longest in human genome. The surprising activity creatinkinase -21-23 000 ME, found by author, make to think of the damage much membranes - damage System. Destroy System D is beginning of the disease, finishing apoptosis - general destructive factor. Two factors determinate the disease –damage the system D and apoptosis.