Open AccessThe Cure of Human Type 2 Diabetes via Systematic Transplantations of dgHPSCs Overexpressing Human ERRy and/or Insulin Genes (I)
Author(s) -
Taihua Wang,
Xiaohui Cui,
Zhenzhen Yang,
Linyu Cui,
Rongrong Li,
Xinyi Shi,
Jiang Xiao-xia,
Shufeng Du,
Mengqian Wang,
Ning Zuo,
Yang Gao,
Ying Meng,
Gang Zhang
Publication year - 2021
Publication title -
stem cell and regenerative medicine
Language(s) - English
Resource type - Journals
ISSN - 2639-9512
DOI - 10.33425/2639-9512.1065
Subject(s) - induced pluripotent stem cell , type 2 diabetes , human insulin , diabetes mellitus , medicine , insulin , genetic enhancement , gene , disease , bioinformatics , stem cell , endocrinology , biology , microbiology and biotechnology , genetics , embryonic stem cell
Although insulin (INS) injection is widely administrated clinically for the treatment of human type 2 diabetes (T2D), this method cannot effectively prohibit the progressing of diabetes complications. Previously, we demonstrated that daily INS injections could be replaced by transplantations of directly-generated human pluripotent stem cells (dgHPSCs) overexpressing human INS and/or estrogen-related receptor γ (ERRγ) genes. In this investigation, we further revealed that systematic transplantations of dgHPSCs overexpressing INS and/or ERRγ genes could completely replaced the INS injections of T2D patient, and the patient’s blood glucose and HbA1c levels were kept around the normal ranges. Hence, this study provided an important strategy for the eventually cure of human T2D disease through human stem cell and gene therapy.