Exosomes: Mechanisms of Uptake | Zendy

Kelly J. McKelvey | Zendy; Katie Powell | Zendy; Anthony W. Ashton | Zendy; Jonathan Morris | Zendy; Sharon A. McCracken | Zendy

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Exosomes: Mechanisms of Uptake

Author(s) -

Kelly J. McKelvey,

Katie Powell,

Anthony W. Ashton,

Jonathan Morris,

Sharon A. McCracken

Publication year - 2015

Publication title -

journal of circulating biomarkers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 11

ISSN - 1849-4544

DOI - 10.33393/jcb.2015.2057

Subject(s) - microvesicles , immune system , exosome , biogenesis , secretion , microrna , biology , rna , microbiology and biotechnology , immunology , genetics , gene , biochemistry

Exosomes are 30–100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

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