Open AccessExosomes: Mechanisms of Uptake
Author(s) -
Kelly McKelvey,
Katie Powell,
Anthony W. Ashton,
Jonathan M. Morris,
Sharon A. McCracken
Publication year - 2015
Publication title -
journal of circulating biomarkers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 11
ISSN - 1849-4544
DOI - 10.33393/jcb.2015.2057
Subject(s) - microvesicles , immune system , exosome , biogenesis , secretion , microrna , biology , rna , microbiology and biotechnology , immunology , genetics , gene , biochemistry
Exosomes are 30–100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.