Open AccessNutrizione parenterale intradialitica in pazienti con malnutrizione moderata-severa: studio prospettico osservazionale multicentrico
Author(s) -
Concetto Sessa,
Walter Morale,
Antonino Reina,
G Battaglia,
Sandra La Rosa,
Daniela Puliatti,
Giuseppe Seminara,
Luca Zanoli
Publication year - 2021
Publication title -
giornale di clinica nefrologica e dialisi
Language(s) - English
Resource type - Journals
ISSN - 2705-0076
DOI - 10.33393/gcnd.2021.2335
Subject(s) - medicine , malnutrition , wasting , multicenter study , creatinine , protein–energy malnutrition , observational study , parenteral nutrition , dialysis , hemodialysis , gastroenterology , albumin , randomized controlled trial
Dialysis patients have a wide range of pathologies that contribute to their frailty. Maintaining a good nutritional status is useful to prevent and treat the so-called Protein-Energy Wasting (PEW), a complex clinical-laboratory condition in which a protein-energy depletion occurs. Adherence to a proper nutritional therapy in CKD requires considerable effort from both patients and health personnel (doctors and nurses). In order to slow down the effects of malnutrition and the disasters that complicate PEW, nephrologists can use supplementation products. In our observational, prospective, multicentre study, we administered an intradialytic parenteral nutrition of a three-compartment emulsion for intravenous infusion through an infusion pump connected to the venous line. After 12 weeks of treatment, subjects with severe malnutrition were reduced from 61.1% to 33.3%, serum creatinine increased by 16% (from 6.00 ± 1.48 mg/dL to 6.98 ± 2.46 mg/dL; P < 0.001), total protein and albumin levels respectively by 13% (from 5.46 ± 0.63 g/dL to 6.19 ± 0.66 g/dL; P < 0.001) and 19% (from 2.70 ± 0.48 g/dL to 3.20 ± 0.57 g/dL; P < 0.001), body weight by 3% (from 55.7 ± 13.2 kg to 57.6 ± 13.0 kg; P < 0.001).