Open AccessManagement of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
Author(s) -
Toshimi Imai,
Tetsu Akimoto,
Chiharu Ito,
Takahiro Masuda,
Daisuke Nagata
Publication year - 2015
Publication title -
drug target insights
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 12
ISSN - 1177-3928
DOI - 10.33393/dti.2015.1410
Subject(s) - medicine , furosemide , dapagliflozin , diuretic , nephrotic syndrome , blockade , urology , diabetes mellitus , endocrinology , intensive care medicine , pediatrics , type 2 diabetes , receptor
A 48-year-old female was admitted to our hospital presenting with a chief complaint of progressive swelling because of diabetic nephrotic syndrome. Dapagliflozin seemed to play a role in accelerating the patient’s urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide. Our experience emphasizes a potential novel approach to overcoming loop diuretic resistance using this agent among some subsets of type 2 diabetic subjects complicated with severe volume accumulation. We believe that combination treatment consisting of dapagliflozin and furosemide may produce diuretic synergy via sequential nephron blockade. The accumulation of more experience with additional cases similar to ours requires continuous and careful attention.