Open AccessDoes Lack of EWSR1-ATF1 Fusion Exclude Diagnosis of Salivary Gland Clear Cell Carcinoma?
Author(s) -
Sibel Şensu,
Nusret Erdoğan,
Kayhan Başak,
Egzona Qipa,
Murat Büyükdoğan
Publication year - 2021
Publication title -
indonesian journal of cancer (e-journal)
Language(s) - English
Resource type - Journals
ISSN - 2355-6811
DOI - 10.33371/ijoc.v15i3.795
Subject(s) - salivary gland , immunohistochemistry , pathology , cytokeratin , clear cell , mucin , acinic cell carcinoma , carcinoma , differential diagnosis , biology , mucoepidermoid carcinoma , medicine
Ewing sarcoma breakpoint region 1- activating transcription factor 1 (EWSR1-ATF1) fusion is mentioned as a diagnostic marker in favor of clear cell carcinoma in the differential diagnosis of clear cell neoplasms of salivary glands. However, in literature, its positivity is reported between 82% and 93%. In salivary glands, various benign and malignant primary tumors, as well as odontogenic neoplasms and metastatic cases, present with a varied number of clear cells. Clear cell carcinoma of the salivary gland is a rare entity with distinct histochemistry and immunohistochemistry features.Case Presentation: We present a clear cell carcinoma of the salivary gland showing cytoplasmic Periodic acid–Schiff (PAS) (+), mucin (-) staining, cytokeratin (CK), CK7, and P63 immunoreactivity without EWSR1-ATF1 fusion. Conclusions: We conclude that clinical, morphological, and immunohistochemical analyses should be the guide for diagnosis even though molecular analysis does not support it.