Cytokine status in patients with generalized periodontitis in the settings of type II diabetes mellitus

. The problem of generalized periodontitis is taking on particular significance due to the data concerning its close connection with somatic diseases, among which diabetes mellitus is particularly important. In studying the pathogenesis of generalized periodontitis in the settings of diabetes mellitus, it is important to determine the synergistic effect of proinflammatory cytokines, which can be markers of local changes and a diagnostic criterion for the severity and activity of the pathological process in the periodontal tissues. The aim of the study was to determine the cytokine profile of oral fluid in patients with generalized periodontitis in the settings of type II diabetes depending on the severity and course of the dystrophic-inflammatory process in periodontal tissues. Materials and methods. To study this issue, a comprehensive clinical and immunological study of 41 patients with generalized periodontitis in the settings of type II diabetes and 10 people with clinically intact periodontal tissues was performed. Results. The development of the pathological process in patients with generalized periodontitis in the settings of diabetes mellitus is accompanied by an increase in the concentration of proinflammatory cytokines in the oral fluid, namely TNF-α, IL-1β, IL-6, which contribute to the progression of dystrophic inflammation in periodontal tissues. The mechanism of pathogenetic correlations substantiates the scientific approach to the choice and application of immunological methods for the study of patients with generalized periodontitis. Conclusions. Level detection of TNF-α, IL-1β, IL-6 pro-inflammatory cytokines in the oral fluid can be a diagnostically important factor in determining the severity of the pathological process and the effectiveness of treatment of patients with generalized periodontitis.