Open AccessPossible hidden cause of human immunodeficiency virus type 1 latency and role of interferon
Author(s) -
Nursarat Ahmed,
Kazuki Miura
Publication year - 2016
Publication title -
mediscope
Language(s) - English
Resource type - Journals
eISSN - 2616-6054
pISSN - 2307-7689
DOI - 10.3329/mediscope.v3i2.30162
Subject(s) - latency (audio) , virology , interferon , virus latency , human immunodeficiency virus (hiv) , biology , phenotype , virus , antiretroviral therapy , immunology , viral replication , viral load , genetics , gene , electrical engineering , engineering
Latent human immunodeficiency virus type 1 (HIV-1) infected cells under antiretroviral therapy are reported to be resting memory CD4+ T cells; however, the mechanisms of HIV-1 latency is unclear. We demonstrate that long-term culture of interleukin-2-dependent CD4+ T cells with a memory phenotype mimicked latently HIV-1-infected cells in the presence of interferon-?. These cells are mostly resting and contained HIV-1 proviruses that could be re-activated by stimulation. Our findings suggest a potential role of type-1 interferon in HIV-1 latency.Mediscope Vol. 3, No. 2: July 2016, Pages 11-17