Open AccessSynthesis and Antimicrobial Activity of 7-Hydroxy-3',4'-Methylenedioxy- and 7-Benzyloxy-3',4'-Methylenedioxy Flavanones
Author(s) -
Raisuddin Ali,
Abdul Rahim,
Ashraful Islam
Publication year - 2017
Publication title -
journal of scientific research
Language(s) - English
Resource type - Journals
eISSN - 2070-0245
pISSN - 2070-0237
DOI - 10.3329/jsr.v9i3.31229
Subject(s) - methylenedioxy , flavanone , antifungal , chalcone , antimicrobial , chemistry , antibacterial activity , stereochemistry , biology , organic chemistry , flavonoid , microbiology and biotechnology , bacteria , alkyl , genetics , halogen , antioxidant
7-Hydroxy-3',4'-methylenedioxy- and 7-benzyloxy-3',4'-methylenedioxy flavanones have been synthesized starting from 2,4-dihydroxyacetophenone. Subsequently biocidal activities of the flavanones have been investigated along with their corresponding chalcones against some bacterial and fungal strains. 2'-Hydroxy-4'-benzyloxy-3,4-methylenedioxy chalcone (5) and its corresponding flavanone (7) showed good antibacterial and antifungal activities against some selected bacterial and fungal strains. On the other hand, 2',4'-dihydroxy-3,4-methylenedioxy chalcone (4) showed no antibacterial and antifungal activities while its corresponding flavanone (6) showed a little antibacterial activity only at higher concentration but did not show antifungal activity. The synthesized chalcones and flavanones have been characterized using UV-Vis, IR and 1H NMRspectral data together with elemental analysis.