Open AccessClinical Value of Serum Cancer Antigen 19-9 as a Tumor Screening Marker among Healthy Individuals
Author(s) -
Prodip Kumar Biswas,
Md Hafiz Sardar,
Gopal Chandra Saha,
Shabbir Hossain,
Mohammad Motlabur Rahman,
Mostofa Kamal Chowdhury,
Tushit Paul
Publication year - 2019
Publication title -
journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.121
H-Index - 5
eISSN - 2075-5384
pISSN - 1997-9797
DOI - 10.3329/jom.v20i2.42009
Subject(s) - medicine , tumor marker , malignancy , cancer , gastroenterology , colorectal cancer , cancer screening , colonoscopy
Background: Serum tumor markers are convenient, non-invasive, acceptable to patients and play an important role as an ancillary tumor diagnostic tool. CA 19-9 has become a common tumor marker, specific for digestive system tumors. The study was carried out to determine the value of CA 19-9 as a tumor screening marker among healthy individuals.
Materials and Methods: This study had been carried in Dhaka Medical college Hospital from January 2016 to January 2018. The serum CA 19-9 level was detected using a microsome luminescence method. Individuals with high CA 19-9 levels underwent further examination, including routine fecal testing, thoracic and abdominal computed tomography (CT) scan, gastroscopy, and colonoscopy. These individuals had regular follow-up examinations.
Results: Over a 3-year period, the serum CA19-9 levels of 960 healthy individuals were estimated. The CA 19-9 level of 15 individuals was positive (positive rate: 1.56%), including 7 men (7/699; 1.001%) and 8 women (8/261; 3.06%). There was a significant difference between males and females (p<0.01), The overall tumor detection rate was 0.72% (7/960) including 6/699 men (0.85%) and 1/261 women (0.38%).
Conclusion: Therefore, elevated CA 19-9 level can be used to assist in the diagnosis malignancy.
J MEDICINE JUL 2019; 20 (2) : 92-94