Open AccessEvans Syndrome
Author(s) -
Ahmedul Kabir,
Jayanta Banik,
Ratan Das Gupta,
Robed Amin,
AM Wasiq Faisal,
ASM Mafidul Islam,
Mustafa Kamal,
Pinaki Paul,
Farzana Chowdhury,
Hasna Hena Parveen
Publication year - 1970
Publication title -
journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.121
H-Index - 5
eISSN - 2075-5384
pISSN - 1997-9797
DOI - 10.3329/jom.v11i1.4280
Subject(s) - evans syndrome , medicine , haemolysis , autoantibody , immunology , autoimmune hemolytic anemia , immunosuppression , spherocytosis , antibody , coombs test , etiology , splenectomy , spleen
Evans' syndrome is a rare autoimmune disorder in which the body makes antibodies that destroy the red blood cells, platelets and white blood cells. Patients are diagnosed with thrombocytopenia and Coombs' positive haemolytic anaemia and have no other known underlying aetiology. We report two cases of autoimmune haemolytic anaemia (AIHA) associated with immune thrombocytopenia which is known as Evans's syndrome. In these patient there were clinical evidence of haemolysis, serum bilirubin was elevated, blood film showed anaemia with trrombocytopenia but no spherocytosis. Immunosuppression was achieved with steroid. We would like to highlight that a negative Coomb's test is now often interpreted as absence of autoantibodies, but it is more or less preclusive for the diagnosis of AIHA. Keywords: Evan's Syndrome, autoimmune haemolytic anaemia DOI:10.3329/jom.v11i1.4280 J Medicine 2010: 11: 78-82